Lectures
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Bioorganic Chemistry: Nucleic Acids
The slides of the lecture for download:
Chapter 1: Introduction
Introduction and historical overview (pdf-Datei, 194 kb)
Chapter 2: Composition and structure of DNA
2-1 General overview (pdf, 283 kb)
2-2 Physical properties of nucleotides (pdf, 409 kb)
2-3 The DNA double helix (pdf, 430 kb)
2-4 Circular DNA and supercoiling (pdf, 336 kb)
2-5 DNA denaturation (pdf, 155 kb)
2-6 DNA organization in the nucleus (pdf, 229 kb)
2-7 DNA with more than two strands (pdf, 874 kb)
Chapter 3: DNA synthesis
3-1 Chemical DNA synthesis (pdf, 811 kb)
3-2 Biological DNA synthesis (pdf, 1559 kb)
Chapter 4: DNA sequencing
DNA sequencing methods (pdf, 903 kb)
Maxam-Gilbert DNA sequencing (pdf, 1118 kb)
Chapter 5: DNA-modifying enzymes
5-1 Restriction endonucleases (pdf, 956 kb)
5-2 DNA Methyltransferases (pdf, 1548 kb)
5-3 DNA Glycosylases (pdf, 428 kb)
Chapter 6: From gene to protein
6-1 Gene expression (pdf, 166 kb)
6-2 Transcription (pdf, 1843 kb)
6-3-1 Translation - t-RNA (pdf, 792 kb)
6-3-2 Translation - Ribosome (pdf, 462 kb)
Chapter 7: Recombinant DNA-Technology
7-1 and 7-2: Vectors (pdf, 739 kb)
7-3: Mutagenesis (pdf, 294 kb)
exercises and answers (pdf, 1298 kb)